Anti-PDCL3 antibody (STJA0009661)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human PDCL3
General Information
| Short Description | Rabbit polyclonal anti-Phosducin-like protein 3 for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PDCL3 |
| Gene ID | 79031 |
| Uniprot ID | PDCL3_HUMAN |
| Immunogen | Synthesized peptide derived from human PDCL3 |
| Specificity | This antibody detects endogenous levels of PDCL3 at Human, Mouse, Rat |
Additional Info
| Post Translational Modifications | N-terminal methionine acetylation destabilizes the protein. |
| Function | Acts as a chaperone for the angiogenic VEGF receptor KDR/VEGFR2, increasing its abundance by inhibiting its ubiquitination and degradation. Inhibits the folding activity of the chaperonin-containing T-complex (CCT) which leads to inhibition of cytoskeletal actin folding. Acts as a chaperone during heat shock alongside HSP90 and HSP40/70 chaperone complexes. Modulates the activation of caspases during apoptosis. |
| Protein Name | Phosducin-Like Protein 3HtphlpPhpl3Viral Iap-Associated Factor 1Viaf-1 |
| Database Links | |
| Cellular Localisation | CytoplasmPerinuclear RegionEndoplasmic Reticulum |
| Alternative Antibody Names | Anti-Phosducin-Like Protein 3 antibodyAnti-Htphlp antibodyAnti-Phpl3 antibodyAnti-Viral Iap-Associated Factor 1 antibodyAnti-Viaf-1 antibodyAnti-PDCL3 antibodyAnti-PhLP2A antibodyAnti-VIAF1 antibody |
Information sourced from Uniprot.org