Anti-PCSK6 antibody (734-784 aa) (STJ193739)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human PCSK6 at the amino acid range 734-784
General Information
| Short Description | Rabbit polyclonal anti-Proprotein convertase subtilisin/kexin type 6 (734-784 aa) for use in WB in Human and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PCSK6 |
| Gene ID | 5046 |
| Uniprot ID | PCSK6_HUMAN |
| Immunogen | Synthesized peptide derived from the human PCSK6 at the amino acid range 734-784 |
| Immunogen Region | 734-784 aa |
| Specificity | This antibody detects endogenous levels of PCSK6 at Human/Rat |
Additional Info
| Function | Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXXKRR consensus motif. Likely functions in the constitutive secretory pathway, with unique restricted distribution in both neuroendocrine and non-neuroendocrine tissues. |
| Protein Name | Proprotein Convertase Subtilisin/Kexin Type 6Paired Basic Amino Acid Cleaving Enzyme 4Subtilisin-Like Proprotein Convertase 4Spc4Subtilisin/Kexin-Like Protease Pace4 |
| Database Links | Reactome: R-HSA-1181150Reactome: R-HSA-167060Reactome: R-HSA-6809371Reactome: R-HSA-8963889 |
| Cellular Localisation | Isoform Pace4a-I: SecretedIsoform Pace4a-Ii: SecretedIsoform Pace4c: Endoplasmic ReticulumNot SecretedRemains Probably In Zymogen Form In Endoplasmic ReticulumIsoform Pace4cs: Endoplasmic ReticulumIsoform Pace4e-I: Endomembrane SystemPeripheral Membrane ProteinRetained Intracellularly Probably Through A Hydrophobic Cluster In Their C-TerminusIsoform Pace4e-Ii: Endomembrane SystemIsoform Pace4b: Secreted |
| Alternative Antibody Names | Anti-Proprotein Convertase Subtilisin/Kexin Type 6 antibodyAnti-Paired Basic Amino Acid Cleaving Enzyme 4 antibodyAnti-Subtilisin-Like Proprotein Convertase 4 antibodyAnti-Spc4 antibodyAnti-Subtilisin/Kexin-Like Protease Pace4 antibodyAnti-PCSK6 antibodyAnti-PACE4 antibody |
Information sourced from Uniprot.org