| Function | Scaffold protein of the presynaptic cytomatrix at the active zone (CAZ) which is the place in the synapse where neurotransmitter is released. After synthesis, participates in the formation of Golgi-derived membranous organelles termed Piccolo-Bassoon transport vesicles (PTVs) that are transported along axons to sites of nascent synaptic contacts. At the presynaptic active zone, regulates the spatial organization of synaptic vesicle cluster, the protein complexes that execute membrane fusion and compensatory endocytosis. Organizes as well the readily releasable pool of synaptic vesicles and safeguards a fraction of them to be not immediately available for action potential-induced release. Also functions in processes other than assembly such as the regulation of specific presynaptic protein ubiquitination by interacting with SIAH1 or the regulation of presynaptic autophagy. Also mediates synapse to nucleus communication leading to reconfiguration of gene expression by associating with the transcriptional corepressor CTBP1 and by subsequently reducing the size of its pool available for nuclear import. |
| Protein Name | Protein PiccoloAczonin |
| Database Links | Reactome: R-HSA-9662360 |
| Cellular Localisation | Presynaptic Active ZoneColocalizes With Bsn In Developing Axons |
| Alternative Antibody Names | Anti-Protein Piccolo antibodyAnti-Aczonin antibodyAnti-PCLO antibodyAnti-ACZ antibodyAnti-KIAA0559 antibody |
Information sourced from Uniprot.org
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