| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-PCGF3 (1-242) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PCGF3 |
| Gene ID: |
10336 |
| Uniprot ID: |
PCGF3_HUMAN |
| Immunogen Region: |
1-242 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-242 of human PCGF3 (NP_006306.2). |
| Immunogen Sequence: |
MLTRKIKLWDINAHITCRLC SGYLIDATTVTECLHTFCRS CLVKYLEENNTCPTCRIVIH QSHPLQYIGHDRTMQDIVYK LVPGLQEAEMRKQREFYHKL GMEVPGDIKGETCSAKQHLD SHRNGETKADDSSNKEAAEE KPEEDNDYHRSDEQVSICLE CNSSKLRGLKRKWIRCSAQA TVLHLKKFIAKKLNLSSFNE LDILCNEEILGKDHTLKFVV VTRWRFKKAPLLLHYRPKM |
| Function | Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones.it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity. Plays a redundant role with PCGF5 as part of a PRC1-like complex that mediates monoubiquitination of histone H2A 'Lys-119' on the X chromosome and is required for normal silencing of one copy of the X chromosome in XX females. |
| Protein Name | Polycomb Group Ring Finger Protein 3Ring Finger Protein 3a |
| Cellular Localisation | NucleusNucleoplasmRecruited By The Non-Coding Rna Xist To Specific Nuclear Foci That Probably Correspond To The Inactivated X Chromosome |
| Alternative Antibody Names | Anti-Polycomb Group Ring Finger Protein 3 antibodyAnti-Ring Finger Protein 3a antibodyAnti-PCGF3 antibodyAnti-RNF3 antibodyAnti-RNF3A antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
