| Function | Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones.it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity. Plays a redundant role with PCGF5 as part of a PRC1-like complex that mediates monoubiquitination of histone H2A 'Lys-119' on the X chromosome and is required for normal silencing of one copy of the X chromosome in XX females. |
| Protein Name | Polycomb Group Ring Finger Protein 3Ring Finger Protein 3a |
| Cellular Localisation | NucleusNucleoplasmRecruited By The Non-Coding Rna Xist To Specific Nuclear Foci That Probably Correspond To The Inactivated X Chromosome |
| Alternative Antibody Names | Anti-Polycomb Group Ring Finger Protein 3 antibodyAnti-Ring Finger Protein 3a antibodyAnti-PCGF3 antibodyAnti-RNF3 antibodyAnti-RNF3A antibody |
Information sourced from Uniprot.org
