Anti-PCF11 antibody (1256-1555) (STJ118960)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal PCF11 (1256-1555) antibody for use in WB and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PCF11 |
| Gene ID | 51585 |
| Uniprot ID | PCF11_HUMAN |
| Immunogen Region | 1256-1555 |
| Immunogen Sequence | PKAYPDNHLSQVDVNELFSK LLKTGILKLSQTDSATTQVS EVTAQPPPEEEEDQNEDQDV PDLTNFTVEELKQRYDSVIN RLYTGIQCYSCGMRFTTSQT DVYADHLDWHYRQNRTEKDV SRKVTHRRWYYSLTDWIEFE EIADLEERAKSQFFEKVHEE VVLKTQEAAKEKEFQSVPAG PAGAVESCEICQEQFEQYWD EEEEEWHLKNAIRVDGKIYH PSCYEDYQNTSSFDCTPSP |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1256-1555 of human PCF11 (NP_056969.2). |
Additional Info
| Post Translational Modifications | Phosphorylation at Ser-120 and/or Thr-121 by WNK1 weakens its association with POLR2A/RNA polymerase II, promoting transcript release from the chromatin template and mRNA export to the cytoplasm. |
| Function | Component of pre-mRNA cleavage complex II, which promotes transcription termination by RNA polymerase II. |
| Protein Name | Pre-Mrna Cleavage Complex 2 Protein Pcf11Pre-Mrna Cleavage Complex Ii Protein Pcf11 |
| Database Links | Reactome: R-HSA-6807505Reactome: R-HSA-72187Reactome: R-HSA-72203Reactome: R-HSA-73856Reactome: R-HSA-77595 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Pre-Mrna Cleavage Complex 2 Protein Pcf11 antibodyAnti-Pre-Mrna Cleavage Complex Ii Protein Pcf11 antibodyAnti-PCF11 antibodyAnti-KIAA0824 antibody |
Information sourced from Uniprot.org