| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PCF11 |
| Gene ID: | 51585 |
| Uniprot ID: | PCF11_HUMAN |
| Immunogen Region: | 1256-1555 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1256-1555 of human PCF11 (NP_056969.2). |
| Immunogen Sequence: | PKAYPDNHLSQVDVNELFSK LLKTGILKLSQTDSATTQVS EVTAQPPPEEEEDQNEDQDV PDLTNFTVEELKQRYDSVIN RLYTGIQCYSCGMRFTTSQT DVYADHLDWHYRQNRTEKDV SRKVTHRRWYYSLTDWIEFE EIADLEERAKSQFFEKVHEE VVLKTQEAAKEKEFQSVPAG PAGAVESCEICQEQFEQYWD EEEEEWHLKNAIRVDGKIYH PSCYEDYQNTSSFDCTPSP |
| Post Translational Modifications | Phosphorylation at Ser-120 and/or Thr-121 by WNK1 weakens its association with POLR2A/RNA polymerase II, promoting transcript release from the chromatin template and mRNA export to the cytoplasm. |
| Function | Component of pre-mRNA cleavage complex II, which promotes transcription termination by RNA polymerase II. |
| Protein Name | Pre-Mrna Cleavage Complex 2 Protein Pcf11Pre-Mrna Cleavage Complex Ii Protein Pcf11 |
| Database Links | Reactome: R-HSA-6807505Reactome: R-HSA-72187Reactome: R-HSA-72203Reactome: R-HSA-73856Reactome: R-HSA-77595 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Pre-Mrna Cleavage Complex 2 Protein Pcf11 antibodyAnti-Pre-Mrna Cleavage Complex Ii Protein Pcf11 antibodyAnti-PCF11 antibodyAnti-KIAA0824 antibody |
Information sourced from Uniprot.org