Anti-PBRM1 antibody (1-230) (STJ111920)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal PBRM1 (1-230) antibody for use in WB, IP and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IP/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IP:0.5 Mu g-4 Mu g antibody for 200 Mu g-400 Mu g extracts of whole cellsELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PBRM1 |
| Gene ID | 55193 |
| Uniprot ID | PB1_HUMAN |
| Immunogen Region | 1-230 |
| Immunogen Sequence | MGSKRRRATSPSSSVSGDFD DGHHSVSTPGPSRKRRRLSN LPTVDPIAVCHELYNTIRDY KDEQGRLLCELFIRAPKRRN QPDYYEVVSQPIDLMKIQQK LKMEEYDDVNLLTADFQLLF NNAKSYYKPDSPEYKAACKL WDLYLRTRNEFVQKGEADDE DDDEDGQDNQGTVTEGSSPA YLKEILEQLLEAIVVATNPS GRLISELFQKLPSKVQYPDY YAIIKEPIDL |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-230 of human PBRM1 (NP_060783.3). |
Additional Info
| Tissue Specificity | Widely expressed. |
| Function | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for the stability of the SWI/SNF chromatin remodeling complex SWI/SNF-B (PBAF). Acts as a negative regulator of cell proliferation. |
| Protein Name | Protein Polybromo-1Hpb1Brg1-Associated Factor 180Baf180Polybromo-1d |
| Database Links | Reactome: R-HSA-3214858Reactome: R-HSA-8939243 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Protein Polybromo-1 antibodyAnti-Hpb1 antibodyAnti-Brg1-Associated Factor 180 antibodyAnti-Baf180 antibodyAnti-Polybromo-1d antibodyAnti-PBRM1 antibodyAnti-BAF180 antibodyAnti-PB1 antibody |
Information sourced from Uniprot.org