| Short Description : | Rabbit monoclonal PAX6 (323-422) antibody for use in WB, IHC-P and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/IHC-P/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | S6MR |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:1000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PAX6 |
| Gene ID: | 5080 |
| Uniprot ID: | PAX6_HUMAN |
| Immunogen Region: | 323-422 |
| Immunogen Sequence: | TNTYSALPPMPSFTMANNLP MQPPVPSQTSSYSCMLPTSP SVNGRSYDTYTPPHMQTHMN SQPMGTSGTTSTGLISPGVS VPVQVPGSEPDMSQYWPRLQ |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 323-422 of human PAX6 (NP_000271.1). |
| Tissue Specificity | Isoform 1: Expressed in lymphoblasts. Isoform 5a: Weakly expressed in lymphoblasts. |
| Post Translational Modifications | Ubiquitinated by TRIM11, leading to ubiquitination and proteasomal degradation. |
| Function | Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells. Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains. Acts as a transcriptional repressor of NFATC1-mediated gene expression. |
| Protein Name | Paired Box Protein Pax-6Aniridia Type Ii ProteinOculorhombin |
| Database Links | Reactome: R-HSA-210745Reactome: R-HSA-381771Reactome: R-HSA-400511Reactome: R-HSA-5617472Reactome: R-HSA-9823739 |
| Cellular Localisation | NucleusIsoform 1: NucleusIsoform 5a: Nucleus |
| Alternative Antibody Names | Anti-Paired Box Protein Pax-6 antibodyAnti-Aniridia Type Ii Protein antibodyAnti-Oculorhombin antibodyAnti-PAX6 antibodyAnti-AN2 antibody |
Information sourced from Uniprot.org
