| Host: | Mouse |
| Applications: | WB/FC/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Mouse monoclonal antibody anti-Paired box protein Pax-6 is suitable for use in Western Blot, Flow Cytometry and ELISA research applications. |
| Clonality : | Monoclonal |
| Clone ID : | 1C8 |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Formulation: | Liquid in PBS containing 0.03% Sodium Azide, 0.5% BSA, 50% Glycerol. |
| Purification: | Affinity purification |
| Dilution Range: | WB 1:500-1:2000 FC 1:200-1:400 ELISA 1:10000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PAX6 |
| Gene ID: | 5080 |
| Uniprot ID: | PAX6_HUMAN |
| Specificity: | Pax-6 Monoclonal Antibody detects endogenous levels of Pax-6 protein. |
| Immunogen: | Purified recombinant fragment of human Pax-6 expressed in E. Coli. |
| Post Translational Modifications | Ubiquitinated by TRIM11, leading to ubiquitination and proteasomal degradation. |
| Function | Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells. Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains. Acts as a transcriptional repressor of NFATC1-mediated gene expression. |
| Protein Name | Paired Box Protein Pax-6 Aniridia Type Ii Protein Oculorhombin |
| Database Links | Reactome: R-HSA-210745 Reactome: R-HSA-381771 Reactome: R-HSA-400511 Reactome: R-HSA-5617472 Reactome: R-HSA-9823739 |
| Cellular Localisation | Nucleus Isoform 1: Nucleus Isoform 5a: Nucleus |
| Alternative Antibody Names | Anti-Paired Box Protein Pax-6 antibody Anti-Aniridia Type Ii Protein antibody Anti-Oculorhombin antibody Anti-PAX6 antibody Anti-AN2 antibody |
Information sourced from Uniprot.org