Anti-PAX4 antibody (50-200) (STJ27367)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal PAX4 (50-200) antibody for use in WB and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PAX4Uniprot ID=PAX4_HUMAN" |
| Immunogen Region | 50-200 |
| Immunogen Sequence | LGRYYRTGVLEPKGIGGSKP RLATPPVVARIAQLKGECPA LFAWEIQRQLCAEGLCTQDK TPSVSSINRVLRALQEDQGL PCTRLRSPAVLAPAVLTPHS GSETPRGTHPGTGHRNRTIF SPSQAEALEKEFQRGQYPDS VARGKLATATS |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 50-200 of human PAX4 (NP_006184.2). |
Additional Info
| Function | Plays an important role in the differentiation and development of pancreatic islet beta cells. Transcriptional repressor that binds to a common element in the glucagon, insulin and somatostatin promoters. Competes with PAX6 for this same promoter binding site. Isoform 2 appears to be a dominant negative form antagonizing PAX4 transcriptional activity. |
| Protein Name | Paired Box Protein Pax-4 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Paired Box Protein Pax-4 antibodyAnti-PAX4 antibody |
Information sourced from Uniprot.org