| Post Translational Modifications | Autophosphorylated on Thr-1161 and Thr-1165. Autophosphorylation is activated by phospholipids. |
| Function | Serine/threonine-protein kinase involved in energy homeostasis and protein translation. Phosphorylates EEF1A1, GYS1, PDX1 and RPS6. Probably plays a role under changing environmental conditions (oxygen, glucose, nutrition), rather than under standard conditions. Acts as a sensor involved in energy homeostasis: regulates glycogen synthase synthesis by mediating phosphorylation of GYS1, leading to GYS1 inactivation. May be involved in glucose-stimulated insulin production in pancreas and regulation of glucagon secretion by glucose in alpha cells.however such data require additional evidences. May play a role in regulation of protein translation by phosphorylating EEF1A1, leading to increase translation efficiency. May also participate in respiratory regulation. |
| Protein Name | Pas Domain-Containing Serine/Threonine-Protein KinasePas-KinasePaskinHpask |
| Cellular Localisation | CytoplasmNucleusLocalizes In The Nucleus Of Testis Germ Cells And In The Midpiece Of Sperm Tails |
| Alternative Antibody Names | Anti-Pas Domain-Containing Serine/Threonine-Protein Kinase antibodyAnti-Pas-Kinase antibodyAnti-Paskin antibodyAnti-Hpask antibodyAnti-PASK antibodyAnti-KIAA0135 antibody |
Information sourced from Uniprot.org
