| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Beta-parvin is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PARVB |
| Gene ID: | 29780 |
| Uniprot ID: | PARVB_HUMAN |
| Specificity: | This antibody detects endogenous levels of PARVB at Human, Mouse |
| Immunogen: | Synthesized peptide derived from human PARVB |
| Function | Adapter protein that plays a role in integrin signaling via ILK and in activation of the GTPases CDC42 and RAC1 by guanine exchange factors, such as ARHGEF6. Is involved in the reorganization of the actin cytoskeleton and formation of lamellipodia. Plays a role in cell adhesion, cell spreading, establishment or maintenance of cell polarity, and cell migration. |
| Protein Name | Beta-ParvinAffixin |
| Database Links | Reactome: R-HSA-446353Reactome: R-HSA-446388 |
| Cellular Localisation | Cell JunctionFocal AdhesionCell MembranePeripheral Membrane ProteinCytoplasmic SideCytoplasmCytoskeletonCell ProjectionLamellipodiumMyofibrilSarcomereZ LineConstituent Of Focal AdhesionsDetected At The Tips Of The Leading Edge Of CellsColocalizes With F-Actin At The Tips Of Lamellipodia |
| Alternative Antibody Names | Anti-Beta-Parvin antibodyAnti-Affixin antibodyAnti-PARVB antibodyAnti-CGI-56 antibody |
Information sourced from Uniprot.org