• Western blot analysis of various lysates using PARVB Rabbit polyclonal antibody (STJ115127) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.

Anti-PARVB antibody (1-100) (STJ115127)

SKU:
STJ115127

£112.50 - £522.50
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Host: Rabbit
Applications: WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-PARVB (1-100) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: PARVB
Gene ID: 29780
Uniprot ID: PARVB_HUMAN
Immunogen Region: 1-100
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-100 of human PARVB (NP_037459.2).
Immunogen Sequence: MSSAPRSPTPRPRRMKKDES FLGKLGGTLARKRRAREVSD LQEEGKNAINSPMSPALVDV HPEDTQLEENEERTMIDPTS KEDPKFKELVKVLLDWINDV
Tissue Specificity Expressed predominantly in heart and skeletal muscle.
Function Adapter protein that plays a role in integrin signaling via ILK and in activation of the GTPases CDC42 and RAC1 by guanine exchange factors, such as ARHGEF6. Is involved in the reorganization of the actin cytoskeleton and formation of lamellipodia. Plays a role in cell adhesion, cell spreading, establishment or maintenance of cell polarity, and cell migration.
Protein Name Beta-Parvin
Affixin
Database Links Reactome: R-HSA-446353
Reactome: R-HSA-446388
Cellular Localisation Cell Junction
Focal Adhesion
Cell Membrane
Peripheral Membrane Protein
Cytoplasmic Side
Cytoplasm
Cytoskeleton
Cell Projection
Lamellipodium
Myofibril
Sarcomere
Z Line
Constituent Of Focal Adhesions
Detected At The Tips Of The Leading Edge Of Cells
Colocalizes With F-Actin At The Tips Of Lamellipodia
Alternative Antibody Names Anti-Beta-Parvin antibody
Anti-Affixin antibody
Anti-PARVB antibody
Anti-CGI-56 antibody

Information sourced from Uniprot.org

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