Anti-PARP2 antibody (N-Term) (STJA0005745)

SKU:
STJA0005745-100

Shipping:
Free Shipping
Current Stock:
Host: Rabbit
Applications: WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-PARP2 (N-Term) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS + 0.02% NaN3
Purification: Antigen Affinity Purified
Dilution Range: WB 1:500-1:1000
IHC
ICC
IP
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: PARP2
Gene ID: 10038
Uniprot ID: PARP2_HUMAN
Immunogen Region: N-Term
Specificity: Reacts with the N-terminal region of the 62 kDa human PARP-2 protein.
Immunogen: Synthetic peptide corresponding to amino acids from the N-terminal region of human PARP-2 protein
Post Translational Modifications Auto poly-ADP-ribosylated on serine residues, leading to dissociation of the PARP2-HPF1 complex from chromatin. Poly-ADP-ribosylated by PARP1. Acetylation reduces DNA binding and enzymatic activity. Proteolytically cleaved by caspase-8 (CASP8) in response to apoptosis, leading to its inactivation.
Function Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair. Mediates glutamate, aspartate or serine ADP-ribosylation of proteins: the ADP-D-ribosyl group of NAD(+) is transferred to the acceptor carboxyl group of target residues and further ADP-ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units. Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage. Mediates glutamate and aspartate ADP-ribosylation of target proteins in absence of HPF1. Following interaction with HPF1, catalyzes serine ADP-ribosylation of target proteins.HPF1 conferring serine specificity by completing the PARP2 active site. PARP2 initiates the repair of double-strand DNA breaks: recognizes and binds DNA breaks within chromatin and recruits HPF1, licensing serine ADP-ribosylation of target proteins, such as histones, thereby promoting decompaction of chromatin and the recruitment of repair factors leading to the reparation of DNA strand breaks. HPF1 initiates serine ADP-ribosylation but restricts the polymerase activity of PARP2 in order to limit the length of poly-ADP-ribose chains. Specifically mediates formation of branched poly-ADP-ribosylation. Branched poly-ADP-ribose chains are specifically recognized by some factors, such as APLF. In addition to proteins, also able to ADP-ribosylate DNA: preferentially acts on 5'-terminal phosphates at DNA strand breaks termini in nicked duplex.
Protein Name Poly Adp-Ribose Polymerase 2
Parp-2
Hparp-2
Adp-Ribosyltransferase Diphtheria Toxin-Like 2
Artd2
Dna Adp-Ribosyltransferase Parp2
Nad(+ Adp-Ribosyltransferase 2
Adprt-2
PolyAdp-Ribose Synthase 2
Padprt-2
Protein Poly-Adp-Ribosyltransferase Parp2
Database Links Reactome: R-HSA-110362
Reactome: R-HSA-5685939
Reactome: R-HSA-5696394
Reactome: R-HSA-5696395
Reactome: R-HSA-5696400
Cellular Localisation Nucleus
Chromosome
Recruited To Dna Damage Sites In A Parp1-Dependent Process: Recognizes And Binds Poly-Adp-Ribose Chains Produced By Parp1 At Dna Damage Sites Via Its N-Terminus
Leading To Its Recruitment
Alternative Antibody Names Anti-Poly Adp-Ribose Polymerase 2 antibody
Anti-Parp-2 antibody
Anti-Hparp-2 antibody
Anti-Adp-Ribosyltransferase Diphtheria Toxin-Like 2 antibody
Anti-Artd2 antibody
Anti-Dna Adp-Ribosyltransferase Parp2 antibody
Anti-Nad(+ Adp-Ribosyltransferase 2 antibody
Anti-Adprt-2 antibody
Anti-PolyAdp-Ribose Synthase 2 antibody
Anti-Padprt-2 antibody
Anti-Protein Poly-Adp-Ribosyltransferase Parp2 antibody
Anti-PARP2 antibody
Anti-ADPRT2 antibody
Anti-ADPRTL2 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance