| Function | Intracellular mono-ADP-ribosyltransferase that plays a role in different processes, such as protein translation and unfolded protein response (UPR), through the mono-ADP-ribosylation of proteins involved in those processes. Acts as an inhibitor of protein translation by catalyzing mono-ADP-ribosylation of ribosomal subunits, such as RPL14 and RPS6, thereby inhibiting polysome assembly and mRNA loading. Mono-ADP-ribosylation of ribosomal subunits is promoted by NMNAT2. Involved in the unfolded protein response (UPR) by ADP-ribosylating and activating EIF2AK3 and ERN1, two important UPR effectors. May also mediate mono-ADP-ribosylation of karyopherin KPNB1 a nuclear import factor. May not modify proteins on arginine or cysteine residues compared to other mono-ADP-ribosyltransferases. |
| Protein Name | Protein Mono-Adp-Ribosyltransferase Parp16Adp-Ribosyltransferase Diphtheria Toxin-Like 15Poly Adp-Ribose Polymerase 16Parp-16 |
| Database Links | Reactome: R-HSA-197264Reactome: R-HSA-9683610Reactome: R-HSA-9694631 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Type Iv Membrane Protein |
| Alternative Antibody Names | Anti-Protein Mono-Adp-Ribosyltransferase Parp16 antibodyAnti-Adp-Ribosyltransferase Diphtheria Toxin-Like 15 antibodyAnti-Poly Adp-Ribose Polymerase 16 antibodyAnti-Parp-16 antibodyAnti-PARP16 antibodyAnti-ARTD15 antibodyAnti-C15orf30 antibody |
Information sourced from Uniprot.org
