Anti-PARP11 antibody (STJ192139)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from part of the human protein
General Information
| Short Description | Rabbit polyclonal anti-Protein mono-ADP-ribosyltransferase PARP11 for use in WB and ELISA in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PARP11 |
| Gene ID | 57097 |
| Uniprot ID | PAR11_HUMAN |
| Immunogen | Synthesized peptide derived from part of the human protein |
| Specificity | PAR11 Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Function | Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins. Plays a role in nuclear envelope stability and nuclear remodeling during spermiogenesis. Inhibits the type I interferon activated signaling pathway. Mechanistically, mono-ADP-ribosylates beta-TrCP/BTRC to promote IFNAR1 ubiquitination and protect BTRC from ubiquitin-proteasome degradation. Additionally, acts as an antiviral factor by cooperating with PARP12 to suppress Zika virus replication, independent of IFNAR1 regulation or intrinsic PARP enzymatic activity. Instead, facilitates the degradation of viral NS1 and NS3 proteins, potentially disrupting viral replication. |
| Protein Name | Protein Mono-Adp-Ribosyltransferase Parp11Adp-Ribosyltransferase Diphtheria Toxin-Like 11Artd11Poly Adp-Ribose Polymerase 11Parp-11 |
| Database Links | |
| Cellular Localisation | NucleusNuclear Pore ComplexColocalizes With Nup153 At Nuclear Pores |
| Alternative Antibody Names | Anti-Protein Mono-Adp-Ribosyltransferase Parp11 antibodyAnti-Adp-Ribosyltransferase Diphtheria Toxin-Like 11 antibodyAnti-Artd11 antibodyAnti-Poly Adp-Ribose Polymerase 11 antibodyAnti-Parp-11 antibodyAnti-PARP11 antibodyAnti-C12orf6 antibody |
Information sourced from Uniprot.org