Anti-Pan-Succinyl-Lysine antibody [SRM14870] {Affinity Gel} (STJ11109600)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationAffinity Gel
ImmunogenSynthetic peptide. This information is considered to be commercially sensitive.
General Information
| Short Description | Rabbit monoclonal Pan-Succinyl-Lysine antibody for use in IP-MS in species independent samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IP-MS |
| Host | Rabbit |
| Reactivity | Species Independent |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SRM14870 |
| Conjugation | Affinity Gel |
| Purification | Affinity purification |
| Dilution Range | IP-MS, 40 Mu L antibody (bead slurry) for 200 Mu g-400 Mu g extracts of whole cell |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Immunogen | Synthetic peptide. This information is considered to be commercially sensitive. |
Additional Info
| Background | The lysine residue in proteins can undergo to many types of PTMs, such as methylation, acetylation, biotinylation, ubiquitination, ubiquitin-like modifications, propionylation and butyrylation, then leading to the remarkable complexity of PTM networks. Succinylation is a posttranslational modification (PTM) where a succinyl group is added to a Lys (K) residue of a protein molecule.it has been shown that the lysine succinylation responses to different physiological conditions and is evolutional conserved. It has been identified 2, 565 succinylation sites from 779 proteins and revealed that lysine succinylation have potential impacts on enzymes involved in mitochondrial metabolism including the amino acid degradation, tricarboxylic acid (TCA) cycle and fatty acid metabolism Thelysine succinylation also occurs in histones, suggesting that it may play an important role in regulating chromatin structures and functions as well |
Information sourced from Uniprot.org