| Short Description : | Rabbit monoclonal Pan-Succinyl Lysine antibody for use in WB, IP, DB and ELISA in human, mouse, rat and other samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/IP/DB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat/Other |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | SRM14508 |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Purification: | Affinity purification |
| Dilution Range: | WB, 1:1000-1:5000DB, 1:500-1:2000IP, 0.5 Mu g-4 Mu g antibody for 200 Mu g-600 Mu g extracts of whole cellsELISA, Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requireme |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Immunogen: | Synthetic peptide. This information is considered to be commercially sensitive. |
| Background | The lysine residue in proteins can undergo to many types of PTMs, such as methylation, acetylation, biotinylation, ubiquitination, ubiquitin-like modifications, propionylation and butyrylation, then leading to the remarkable complexity of PTM networks. Succinylation is a posttranslational modification (PTM) where a succinyl group is added to a Lys (K) residue of a protein molecule.it has been shown that the lysine succinylation responses to different physiological conditions and is evolutional conserved.? It has benn identified 2, 565 succinylation sites from 779 proteins and revealed that lysine succinylation have potential impacts on enzymes involved in mitochondrial metabolism including the amino acid degradation, tricarboxylic acid (TCA) cycle and fatty acid metabolism Thelysine succinylation also occurs in histones, suggesting that it may play an important role in regulating chromatin structures and functions as well |
Information sourced from Uniprot.org
