Name: Anti-pan-RAS antibody (1-186aa) [AT2G9] (STJA0041946)
SKU: STJA0041946
Availability: InStock

General Information
Product Properties
Target Information
Additional Info
Citations
Product Review

Short Description :	Mouse monoclonal anti-pan-RAS (1-186aa) for use in ELISA, WB and FACS in Human samples. Datasheet included with dilution recommendations, and related reagents.
Applications:	ELISA/WB/FACS
Host:	Mouse
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Clonality :	Monoclonal
Clone ID :	AT2G9
Isotype:	IgG2ak
Conjugation:	Unconjugated
Concentration:	1 mg/mL
Purification:	By protein-A affinity chromatography
Formulation:	Liquid in phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% Glycerol
Storage Instruction:	For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.

Gene Symbol:	NRAS
Gene ID:	4893
Uniprot ID:	RASN_HUMAN
Accession Number:	NP_002515
Immunogen:	Recombinant human NRAS (1-186aa) purified from E. coli
Immunogen Region:	1-186aa

Post Translational Modifications	Palmitoylated by the ZDHHC9-GOLGA7 complex. Depalmitoylated by ABHD17A, ABHD17B and ABHD17C. A continuous cycle of de- and re-palmitoylation regulates rapid exchange between plasma membrane and Golgi. Acetylation at Lys-104 prevents interaction with guanine nucleotide exchange factors (GEFs). Fatty-acylated at Lys-169 and/or Lys-170. Ubiquitinated by the BCR(LZTR1) E3 ubiquitin ligase complex at Lys-170 in a non-degradative manner, leading to inhibit Ras signaling by decreasing Ras association with membranes. Phosphorylation at Ser-89 enhances NRAS association with its downstream effectors. (Microbial infection) Glucosylated at Thr-35 by P.sordellii toxin TcsL.
Function	Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.
Protein Name	Gtpase Nras Transforming Protein N-Ras
Database Links	Reactome: R-HSA-112412 Reactome: R-HSA-1169092 Reactome: R-HSA-1236382 Reactome: R-HSA-1250196 Reactome: R-HSA-1250347 Reactome: R-HSA-1433557 Reactome: R-HSA-167044 Reactome: R-HSA-171007 Reactome: R-HSA-179812 Reactome: R-HSA-180336 Reactome: R-HSA-186763 Reactome: R-HSA-1963640 Reactome: R-HSA-210993 Reactome: R-HSA-2179392 Reactome: R-HSA-2424491 Reactome: R-HSA-2428933 Reactome: R-HSA-2871796 Reactome: R-HSA-375165 Reactome: R-HSA-442982 Reactome: R-HSA-5218921 Reactome: R-HSA-5621575 Reactome: R-HSA-5637810 Reactome: R-HSA-5654688 Reactome: R-HSA-5654693 Reactome: R-HSA-5654699 Reactome: R-HSA-5654700 Reactome: R-HSA-5654704 Reactome: R-HSA-5654706 Reactome: R-HSA-5654712 Reactome: R-HSA-5654719 Reactome: R-HSA-5655253 Reactome: R-HSA-5655291 Reactome: R-HSA-5655302 Reactome: R-HSA-5655332 Reactome: R-HSA-5658442 Reactome: R-HSA-5673000 Reactome: R-HSA-5673001 Reactome: R-HSA-5674135 Reactome: R-HSA-5675221 Reactome: R-HSA-6798695 Reactome: R-HSA-6802946 Reactome: R-HSA-6802948 Reactome: R-HSA-6802952 Reactome: R-HSA-6802953 Reactome: R-HSA-6802955 Reactome: R-HSA-74751 Reactome: R-HSA-8849471 Reactome: R-HSA-8851805 Reactome: R-HSA-9026519 Reactome: R-HSA-9027284 Reactome: R-HSA-9028731 Reactome: R-HSA-9034864 Reactome: R-HSA-9607240 Reactome: R-HSA-9634285 Reactome: R-HSA-9634635 Reactome: R-HSA-9648002 Reactome: R-HSA-9649948 Reactome: R-HSA-9656223 Reactome: R-HSA-9664565 Reactome: R-HSA-9665348 Reactome: R-HSA-9665686 Reactome: R-HSA-9670439 Reactome: R-HSA-9673767 Reactome: R-HSA-9673770 Reactome: R-HSA-9703465 Reactome: R-HSA-9703648 Reactome: R-HSA-9753510 Reactome: R-HSA-9753512
Cellular Localisation	Cell Membrane Lipid-Anchor Cytoplasmic Side Golgi Apparatus Membrane Shuttles Between The Plasma Membrane And The Golgi Apparatus
Alternative Antibody Names	Anti-Gtpase Nras antibody Anti-Transforming Protein N-Ras antibody Anti-NRAS antibody Anti-HRAS1 antibody

Information sourced from Uniprot.org

View product citations for antibody STJA0041946 on CiteAb

Anti-pan-RAS antibody (1-186aa) [AT2G9] (STJA0041946)

General Information

Product Properties

Target Information

Additional Info

Citations

Product Review

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Model	Name	Host	Clonality	Reactivity	Application
STJA0041606	Anti-pan-RAS antibody (1-186aa) [AT2G9] (STJA0041606)	Mouse	Monoclonal	Human	ELISA/WB/ICC/IF/FACS
STJA0041727	Anti-Ras antibody (1-186aa) [AT2F8] (STJA0041727)	Mouse	Monoclonal	Human	ELISA/WB/ICC/IF
STJA0041706	Anti-CD46 antibody (35-313aa) [AT2G9] (STJA0041706)	Mouse	Monoclonal	Human	ELISA/WB/ICC/IF/IHC/FACS
STJA0033656	Anti-Ras-G12D Mutant antibody (STJA0033656)	Mouse	Monoclonal	Vertebrates	WB/IHC-P/ICC/IF/ELISA
STJA0033662	Anti-Ras-Q61H Mutant antibody (STJA0033662)	Mouse	Monoclonal	Vertebrates	WB/IHC-P/ICC/IF/ELISA