ICC IF of RAS in HeLa cells stained with STJA0041606 antibody Alexa Fluor 488 secondary green DAPI nucleus blue

Anti-pan-RAS antibody (1-186aa) [AT2G9] (STJA0041606)

Name: Anti-pan-RAS antibody (1-186aa) [AT2G9] (STJA0041606)
SKU: STJA0041606
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

ClonalityMonoclonal

HostMouse

ConjugationUnconjugated

IsotypeIgG2ak

ImmunogenRecombinant human NRAS (1-186aa) purified from E. coli

STJA0041606

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General Information

Short Description	Mouse monoclonal anti-pan-RAS (1-186aa) for use in ELISA, WB, ICC, IF and FACS in Human samples. Datasheet included with dilution recommendations, and related reagents.
Applications	ELISA/WB/ICC/IF/FACS
Host	Mouse
Reactivity	Human
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Product Properties

Clonality	Monoclonal
Clone ID	AT2G9
Isotype	IgG2ak
Conjugation	Unconjugated
Concentration	1 mg/mL
Purification	By protein-G affinity chromatography
Formulation	Liquid in phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% Glycerol
Storage Instruction	For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.

Target Information

Gene Symbol	NRAS
Gene ID	4893
Uniprot ID	RASN_HUMAN
Accession Number	NP_002515
Immunogen	Recombinant human NRAS (1-186aa) purified from E. coli
Immunogen Region	1-186aa

Additional Info

Post Translational Modifications	Palmitoylated by the ZDHHC9-GOLGA7 complex. Depalmitoylated by ABHD17A, ABHD17B and ABHD17C. A continuous cycle of de- and re-palmitoylation regulates rapid exchange between plasma membrane and Golgi. Acetylation at Lys-104 prevents interaction with guanine nucleotide exchange factors (GEFs). Fatty-acylated at Lys-169 and/or Lys-170. Ubiquitinated by the BCR(LZTR1) E3 ubiquitin ligase complex at Lys-170 in a non-degradative manner, leading to inhibit Ras signaling by decreasing Ras association with membranes. Phosphorylation at Ser-89 enhances NRAS association with its downstream effectors. (Microbial infection) Glucosylated at Thr-35 by P.sordellii toxin TcsL.
Function	Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.
Protein Name	Gtpase Nras Transforming Protein N-Ras
Database Links	Reactome: R-HSA-112412 Reactome: R-HSA-1169092 Reactome: R-HSA-1236382 Reactome: R-HSA-1250196 Reactome: R-HSA-1250347 Reactome: R-HSA-1433557 Reactome: R-HSA-167044 Reactome: R-HSA-171007 Reactome: R-HSA-179812 Reactome: R-HSA-180336 Reactome: R-HSA-186763 Reactome: R-HSA-1963640 Reactome: R-HSA-210993 Reactome: R-HSA-2179392 Reactome: R-HSA-2424491 Reactome: R-HSA-2428933 Reactome: R-HSA-2871796 Reactome: R-HSA-375165 Reactome: R-HSA-442982 Reactome: R-HSA-5218921 Reactome: R-HSA-5621575 Reactome: R-HSA-5637810 Reactome: R-HSA-5654688 Reactome: R-HSA-5654693 Reactome: R-HSA-5654699 Reactome: R-HSA-5654700 Reactome: R-HSA-5654704 Reactome: R-HSA-5654706 Reactome: R-HSA-5654712 Reactome: R-HSA-5654719 Reactome: R-HSA-5655253 Reactome: R-HSA-5655291 Reactome: R-HSA-5655302 Reactome: R-HSA-5655332 Reactome: R-HSA-5658442 Reactome: R-HSA-5673000 Reactome: R-HSA-5673001 Reactome: R-HSA-5674135 Reactome: R-HSA-5675221 Reactome: R-HSA-6798695 Reactome: R-HSA-6802946 Reactome: R-HSA-6802948 Reactome: R-HSA-6802952 Reactome: R-HSA-6802953 Reactome: R-HSA-6802955 Reactome: R-HSA-74751 Reactome: R-HSA-8849471 Reactome: R-HSA-8851805 Reactome: R-HSA-9026519 Reactome: R-HSA-9027284 Reactome: R-HSA-9028731 Reactome: R-HSA-9034864 Reactome: R-HSA-9607240 Reactome: R-HSA-9634285 Reactome: R-HSA-9634635 Reactome: R-HSA-9648002 Reactome: R-HSA-9649948 Reactome: R-HSA-9656223 Reactome: R-HSA-9664565 Reactome: R-HSA-9665348 Reactome: R-HSA-9665686 Reactome: R-HSA-9670439 Reactome: R-HSA-9673767 Reactome: R-HSA-9673770 Reactome: R-HSA-9703465 Reactome: R-HSA-9703648 Reactome: R-HSA-9753510 Reactome: R-HSA-9753512
Cellular Localisation	Cell Membrane Lipid-Anchor Cytoplasmic Side Golgi Apparatus Membrane Shuttles Between The Plasma Membrane And The Golgi Apparatus
Alternative Antibody Names	Anti-Gtpase Nras antibody Anti-Transforming Protein N-Ras antibody Anti-NRAS antibody Anti-HRAS1 antibody

Information sourced from Uniprot.org

Citations

View product citations for antibody STJA0041606 on CiteAb