Anti-Pan-Lactic Acid-Lysine antibody [SRM5229] {Magnetic Beads} (STJ11107111)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationMagnetic Beads
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal Pan-Lactic Acid-Lysine antibody for use in IP in human, mouse, rat and other samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IP |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat/Other |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SRM5229 |
| Isotype | IgG |
| Conjugation | Magnetic Beads |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | IP:30ul antibody (bead slurry) for 200 Mu g-400 Mu g extracts of whole cells |
| Formulation | PBS with 0.05% Proclin300, pH 7.3. |
Target Information
| Specificity | A synthetic peptide corresponding to a sequence containing Pan Lactic acid-Lysine. |
Additional Info
| Background | Histone lysine lactation (Kla) is a newly discovered histone modification that regulates gene expression in macrophages. In M1 macrophages, lactic acid is derived from incompletely oxidized glucose and then produces lactyl-CoA, which is transferred via acetyltransferase p300 to the lysine tail of the histone. This modification is abundant in gene promoter regions that lack acetylation and are associated with gene expression activation. |
Information sourced from Uniprot.org