| Host: | Rabbit |
| Applications: | IP |
| Reactivity: | Human/Mouse/Rat/Other |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | SRM |
| Conjugation: | Magnetic Beads |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | IP:30ul antibody (bead slurry) for 200 Mu g-400 Mu g extracts of whole cells |
| Specificity: | A synthetic peptide corresponding to a sequence containing Pan Lactic acid-Lysine. |
| Background | Histone lysine lactation (Kla) is a newly discovered histone modification that regulates gene expression in macrophages. In M1 macrophages, lactic acid is derived from incompletely oxidized glucose and then produces lactyl-CoA, which is transferred via acetyltransferase p300 to the lysine tail of the histone. This modification is abundant in gene promoter regions that lack acetylation and are associated with gene expression activation. |
Information sourced from Uniprot.org