| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PALM |
| Gene ID: | 5064 |
| Uniprot ID: | PALM_HUMAN |
| Immunogen Region: | 1-387 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-387 of human PALM (NP_002570.2). |
| Immunogen Sequence: | MEVLAAETTSQQERLQAIAE KRKRQAEIENKRRQLEDERR QLQHLKSKALRERWLLEGTP SSASEGDEDLRRQMQDDEQK TRLLEDSVSRLEKEIEVLER GDSAPATAKENAAAPSPVRA PAPSPAKEERKTEVVMNSQQ TPVGTPKDKRVSNTPLRTVD GSPMMKAAMYSVEITVEKDK VTGETRVLSSTTLLPRQPLP LGIKVYEDETKVVHAVDGTA ENGIHPLSSSEVDELIHKA |
| Tissue Specificity | Widely expressed with highest expression in brain and testis and intermediate expression in heart and adrenal gland. |
| Function | Involved in plasma membrane dynamics and cell process formation. Isoform 1 and isoform 2 are necessary for axonal and dendritic filopodia induction, for dendritic spine maturation and synapse formation in a palmitoylation-dependent manner. |
| Protein Name | Paralemmin-1Paralemmin |
| Cellular Localisation | Cell MembraneLipid-AnchorCytoplasmic SideCell ProjectionFilopodium MembraneAxonDendriteDendritic SpineBasolateral Cell MembraneApicolateral Cell MembraneTranslocation To The Plasma Membrane Is Enhanced Upon Stimulation Of Neuronal Activity |
| Alternative Antibody Names | Anti-Paralemmin-1 antibodyAnti-Paralemmin antibodyAnti-PALM antibodyAnti-KIAA0270 antibody |
Information sourced from Uniprot.org