Anti-PAK6 antibody (1-270) (STJ110131)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal PAK6 (1-270) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PAK6 |
| Gene ID | 106821730/56924 |
| Uniprot ID | PAK6_HUMAN |
| Immunogen Region | 1-270 |
| Immunogen Sequence | MFRKKKKKRPEISAPQNFQH RVHTSFDPKEGKFVGLPPQW QNILDTLRRPKPVVDPSRIT RVQLQPMKTVVRGSAMPVDG YISGLLNDIQKLSVISSNTL RGRSPTSRRRAQSLGLLGDE HWATDPDMYLQSPQSERTDP HGLYLSCNGGTPAGHKQMPW PEPQSPRVLPNGLAAKAQSL GPAEFQGASQRCLQLGACLQ SSPPGASPPTGTNRHGMKAA KHGSEEARPQSCLVGSATG |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human PAK6 (NP_064553.1). |
Additional Info
| Tissue Specificity | Selectively expressed in brain and testis, with lower levels in multiple tissues including prostate and breast. |
| Post Translational Modifications | Autophosphorylated. Phosphorylated by MAP2K6//MAPKK6, leading to PAK6 activation. |
| Function | Serine/threonine protein kinase that plays a role in the regulation of gene transcription. The kinase activity is induced by various effectors including AR or MAP2K6/MAPKK6. Phosphorylates the DNA-binding domain of androgen receptor/AR and thereby inhibits AR-mediated transcription. Also inhibits ESR1-mediated transcription. May play a role in cytoskeleton regulation by interacting with IQGAP1. May protect cells from apoptosis through phosphorylation of BAD. |
| Protein Name | Serine/Threonine-Protein Kinase Pak 6Pak-5P21-Activated Kinase 6Pak-6 |
| Database Links | Reactome: R-HSA-428540Reactome: R-HSA-9013148Reactome: R-HSA-9013149Reactome: R-HSA-9013405Reactome: R-HSA-9013407Reactome: R-HSA-9013424 |
| Cellular Localisation | CytoplasmNucleusCotranslocates Into Nucleus With Ar In Response To Androgen Induction |
| Alternative Antibody Names | Anti-Serine/Threonine-Protein Kinase Pak 6 antibodyAnti-Pak-5 antibodyAnti-P21-Activated Kinase 6 antibodyAnti-Pak-6 antibodyAnti-PAK6 antibodyAnti-PAK5 antibody |
Information sourced from Uniprot.org