| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-PAK1IP1 (1-392) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PAK1IP1 |
| Gene ID: |
55003 |
| Uniprot ID: |
PK1IP_HUMAN |
| Immunogen Region: |
1-392 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-392 of human PAK1IP1 (NP_060376.2). |
| Immunogen Sequence: |
MELVAGCYEQVLFGFAVHPE PEACGDHEQWTLVADFTHHA HTASLSAVAVNSRFVVTGSK DETIHIYDMKKKIEHGALVH HSGTITCLKFYGNRHLISGA EDGLICIWDAKKWECLKSIK AHKGQVTFLSIHPSGKLALS VGTDKTLRTWNLVEGRSAFI KNIKQNAHIVEWSPRGEQYV VIIQNKIDIYQLDTASISGT ITNEKRISSVKFLSESVLAV AGDEEVIRFFDCDSLVCLC |
| Tissue Specificity | Expressed in brain, colon, heart, kidney, liver, lung, muscle, peripheral blood leukocytes, placenta, small intestine, spleen and thymus. |
| Function | Negatively regulates the PAK1 kinase. PAK1 is a member of the PAK kinase family, which has been shown to play a positive role in the regulation of signaling pathways involving MAPK8 and RELA. PAK1 exists as an inactive homodimer, which is activated by binding of small GTPases such as CDC42 to an N-terminal regulatory domain. PAK1IP1 also binds to the N-terminus of PAK1, and inhibits the specific activation of PAK1 by CDC42. May be involved in ribosomal large subunit assembly. |
| Protein Name | P21-Activated Protein Kinase-Interacting Protein 1Pak/Plc-Interacting Protein 1Hpip1Pak1-Interacting Protein 1Wd Repeat-Containing Protein 84 |
| Cellular Localisation | NucleusNucleolus |
| Alternative Antibody Names | Anti-P21-Activated Protein Kinase-Interacting Protein 1 antibodyAnti-Pak/Plc-Interacting Protein 1 antibodyAnti-Hpip1 antibodyAnti-Pak1-Interacting Protein 1 antibodyAnti-Wd Repeat-Containing Protein 84 antibodyAnti-PAK1IP1 antibodyAnti-PIP1 antibodyAnti-WDR84 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
