| Tissue Specificity | Expressed at highest level in testis, but also abundant in brain, cervix, lung, ovary, placenta, adipose tissue, thymus and thyroid. |
| Post Translational Modifications | Ubiquitinated, leading to its degradation by the proteasome. |
| Function | Acts as a repressor in the regulation of translation initiation of poly(A)-containing mRNAs. Its inhibitory activity on translation is mediated via its action on PABPC1. Displaces the interaction of PABPC1 with poly(A) RNA and competes with PAIP1 for binding to PABPC1. Its association with PABPC1 results in disruption of the cytoplasmic poly(A) RNP structure organization. |
| Protein Name | Polyadenylate-Binding Protein-Interacting Protein 2Pabp-Interacting Protein 2Paip-2Poly(A-Binding Protein-Interacting Protein 2 |
| Database Links | |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Polyadenylate-Binding Protein-Interacting Protein 2 antibodyAnti-Pabp-Interacting Protein 2 antibodyAnti-Paip-2 antibodyAnti-Poly(A-Binding Protein-Interacting Protein 2 antibodyAnti-PAIP2 antibodyAnti-PAIP2A antibodyAnti-HSPC218 antibody |
Information sourced from Uniprot.org
