| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Rat/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-PAXIP1-associated glutamate-rich protein 1 (163-213 aa) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PAGR1 |
| Gene ID: |
79447 |
| Uniprot ID: |
PAGR1_HUMAN |
| Immunogen Region: |
163-213 aa |
| Specificity: |
This antibody detects endogenous levels of PA1 at Human |
| Immunogen: |
Synthesized peptide derived from the human PA1 at the amino acid range 163-213 |
| Function | Its association with the histone methyltransferase MLL2/MLL3 complex is suggesting a role in epigenetic transcriptional activation. However, in association with PAXIP1/PTIP is proposed to function at least in part independently of the MLL2/MLL3 complex. Proposed to be recruited by PAXIP1 to sites of DNA damage where the PAGR1:PAXIP1 complex is required for cell survival in response to DNA damage independently of the MLL2/MLL3 complex. However, its function in DNA damage has been questioned. During immunoglobulin class switching in activated B-cells is involved in transcription regulation of downstream switch regions at the immunoglobulin heavy-chain (Igh) locus independently of the MLL2/MLL3 complex. Involved in both estrogen receptor-regulated gene transcription and estrogen-stimulated G1/S cell-cycle transition. Acts as a transcriptional cofactor for nuclear hormone receptors. Inhibits the induction properties of several steroid receptors such as NR3C1, AR and PPARG.the mechanism of inhibition appears to be gene-dependent. |
| Protein Name | Paxip1-Associated Glutamate-Rich Protein 1Glutamate-Rich Coactivator Interacting With Src1GasPaxip1-Associated Protein 1Ptip-Associated Protein 1 |
| Database Links | Reactome: R-HSA-5617472Reactome: R-HSA-9772755 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Paxip1-Associated Glutamate-Rich Protein 1 antibodyAnti-Glutamate-Rich Coactivator Interacting With Src1 antibodyAnti-Gas antibodyAnti-Paxip1-Associated Protein 1 antibodyAnti-Ptip-Associated Protein 1 antibodyAnti-PAGR1 antibodyAnti-C16orf53 antibodyAnti-PA1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
