| Tissue Specificity | Widely expressed. |
| Post Translational Modifications | Phosphorylated by casein kinase 2 (CK2). Phosphorylation by PKC probably decreases the membrane binding and tubulation capacities of PACSIN2, thereby modulating the lifetime of caveolae. |
| Function | Regulates the morphogenesis and endocytosis of caveolae. Lipid-binding protein that is able to promote the tubulation of the phosphatidic acid-containing membranes it preferentially binds. Plays a role in intracellular vesicle-mediated transport. Involved in the endocytosis of cell-surface receptors like the EGF receptor, contributing to its internalization in the absence of EGF stimulus. (Microbial infection) Specifically enhances the efficiency of HIV-1 virion spread by cell-to-cell transfer. Also promotes the protrusion engulfment during cell-to-cell spread of bacterial pathogens like Listeria monocytogenes. Involved in lipid droplet formation, which is important for HCV virion assembly. |
| Protein Name | Protein Kinase C And Casein Kinase Substrate In Neurons Protein 2Syndapin-2Syndapin-IiSdpii |
| Database Links | Reactome: R-HSA-8856828 |
| Cellular Localisation | CytoplasmCytoskeletonCytoplasmic Vesicle MembranePeripheral Membrane ProteinCytoplasmic SideEarly EndosomeRecycling Endosome MembraneCell ProjectionRuffle MembraneCell MembraneMembraneCaveolaDetected At The Neck Of Flask-Shaped CaveolaeLocalization To Tubular Recycling Endosomes Probably Requires Interaction With Micall1 And Ehd1 |
| Alternative Antibody Names | Anti-Protein Kinase C And Casein Kinase Substrate In Neurons Protein 2 antibodyAnti-Syndapin-2 antibodyAnti-Syndapin-Ii antibodyAnti-Sdpii antibodyAnti-PACSIN2 antibody |
Information sourced from Uniprot.org
![Western blot analysis of lysates from wild type (WT) and PACSIN2 knockout (KO) HeLa cells, using [KO Validated] PACSIN2 Rabbit polyclonal antibody (STJ11100817) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1s.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/89753/358230/STJ11100817_1__18149.1713122560.jpg?c=1 "Western blot analysis of lysates from wild type (WT) and PACSIN2 knockout (KO) HeLa cells, using [KO Validated] PACSIN2 Rabbit polyclonal antibody (STJ11100817) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1s.")
![Western blot analysis of lysates from wild type (WT) and PACSIN2 knockout (KO) HeLa cells, using [KO Validated] PACSIN2 Rabbit polyclonal antibody (STJ11100817) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1s.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/89753/358230/STJ11100817_1__18149.1713122560.jpg?c=1 "Western blot analysis of lysates from wild type (WT) and PACSIN2 knockout (KO) HeLa cells, using [KO Validated] PACSIN2 Rabbit polyclonal antibody (STJ11100817) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1s.")
