| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-PABPN1 (1-100) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PABPN1 |
| Gene ID: |
8106 |
| Uniprot ID: |
PABP2_HUMAN |
| Immunogen Region: |
1-100 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human PABPN1 (NP_004634.1). |
| Immunogen Sequence: |
MAAAAAAAAAAGAAGGRGSG PGRRRHLVPGAGGEAGEGAP GGAGDYGNGLESEELEPEEL LLEPEPEPEPEEEPPRPRAP PGAPGPGPGSGAPGSQEEEE |
| Tissue Specificity | Ubiquitous. |
| Post Translational Modifications | Arginine dimethylation is asymmetric and involves PRMT1 and PRMT3. It does not influence the RNA binding properties. |
| Function | Involved in the 3'-end formation of mRNA precursors (pre-mRNA) by the addition of a poly(A) tail of 200-250 nt to the upstream cleavage product. Stimulates poly(A) polymerase (PAPOLA) conferring processivity on the poly(A) tail elongation reaction and controls also the poly(A) tail length. Increases the affinity of poly(A) polymerase for RNA. Is also present at various stages of mRNA metabolism including nucleocytoplasmic trafficking and nonsense-mediated decay (NMD) of mRNA. Cooperates with SKIP to synergistically activate E-box-mediated transcription through MYOD1 and may regulate the expression of muscle-specific genes. Binds to poly(A) and to poly(G) with high affinity. May protect the poly(A) tail from degradation. Subunit of the trimeric poly(A) tail exosome targeting (PAXT) complex, a complex that directs a subset of long and polyadenylated poly(A) RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor MTREX, which links to RNA-binding protein adapters. |
| Protein Name | Polyadenylate-Binding Protein 2Pabp-2Poly(A-Binding Protein 2Nuclear Poly(A-Binding Protein 1Poly(A-Binding Protein IiPabiiPolyadenylate-Binding Nuclear Protein 1 |
| Database Links | Reactome: R-HSA-168315Reactome: R-HSA-72187Reactome: R-HSA-72203Reactome: R-HSA-73856Reactome: R-HSA-77595 |
| Cellular Localisation | NucleusCytoplasmNucleus SpeckleLocalized In Cytoplasmic Mrnp Granules Containing Untranslated MrnasShuttles Between The Nucleus And The Cytoplasm But Predominantly Found In The NucleusIts Nuclear Import May Involve The Nucleocytoplasmic Transport Receptor Transportin And A Ran-Gtp-Sensitive Import MechanismIs Exported To The Cytoplasm By A Carrier-Mediated Pathway That Is Independent Of Mrna TrafficColocalizes With Skip And Poly(A) Rna In Nuclear SpecklesIntranuclear Filamentous Inclusions Or 'Aggregates' Are Detected In The Myocytes Of PatientsThese Inclusions Contain Pabpn1UbiquitinSubunits Of The Proteasome And Poly(A) Rna |
| Alternative Antibody Names | Anti-Polyadenylate-Binding Protein 2 antibodyAnti-Pabp-2 antibodyAnti-Poly(A-Binding Protein 2 antibodyAnti-Nuclear Poly(A-Binding Protein 1 antibodyAnti-Poly(A-Binding Protein Ii antibodyAnti-Pabii antibodyAnti-Polyadenylate-Binding Nuclear Protein 1 antibodyAnti-PABPN1 antibodyAnti-PAB2 antibodyAnti-PABP2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
