Anti-P4HTM antibody (294-563) (STJ115554)

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STJ115554
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Host: Rabbit
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: P4HTM
Gene ID: 54681
Uniprot ID: P4HTM_HUMAN
Immunogen Region: 294-563
Specificity: Recombinant fusion protein containing a sequence corresponding to amino acids 294-563 of human P4HTM (NP_808807.2).
Immunogen Sequence: RQRVLRLTRLSPEIVELSEP LQVVRYGEGGHYHAHVDSGP VYPETICSHTKLVANESVPF ETSCRQVSPNWGLPSILRPG TPMTQAQPCTVGVPLGMGPG DHWVIPVSPWEHPQLGTCSV PPLPYSYMTVLFYLNNVTGG GETVFPVADNRTYDEMSLIQ DDVDLRDTRRHCDKGNLRVK PQQGTAVFWYNYLPDGQGWV GDVDDYSLHGGCLVTRGTKW IANNWINVDPSRARQALFQ
Tissue Specificity Widely expressed with highest levels in adult pancreas, heart, skeletal muscle, brain, placenta, kidney and adrenal gland. Expressed at lower levels in epiphyseal cartilage and in fibroblasts.
Post Translational Modifications Glycosylated.
Function Catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates HIF1A at 'Pro-402' and 'Pro-564'. May function as a cellular oxygen sensor and, under normoxic conditions, may target HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex.
Protein Name Transmembrane Prolyl 4-Hydroxylase
P4h-Tm
Hypoxia-Inducible Factor Prolyl Hydroxylase 4
Hif-Ph4
Hif-Prolyl Hydroxylase 4
Hph-4
Cellular Localisation Endoplasmic Reticulum Membrane
Single-Pass Type Ii Membrane Protein
Alternative Antibody Names Anti-Transmembrane Prolyl 4-Hydroxylase antibody
Anti-P4h-Tm antibody
Anti-Hypoxia-Inducible Factor Prolyl Hydroxylase 4 antibody
Anti-Hif-Ph4 antibody
Anti-Hif-Prolyl Hydroxylase 4 antibody
Anti-Hph-4 antibody
Anti-P4HTM antibody
Anti-PH4 antibody

Information sourced from Uniprot.org

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