| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Protein disulfide-isomerase is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
P4HB |
| Gene ID: |
5034 |
| Uniprot ID: |
PDIA1_HUMAN |
| Specificity: |
This antibody detects endogenous levels of PDI at Human, Mouse, Rat |
| Immunogen: |
Synthesized peptide derived from human PDI |
| Function | This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations and following phosphorylation by FAM20C, functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. Also acts as a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP. Receptor for LGALS9.the interaction retains P4HB at the cell surface of Th2 T helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migration. |
| Protein Name | Protein Disulfide-IsomerasePdiCellular Thyroid Hormone-Binding ProteinProlyl 4-Hydroxylase Subunit BetaP55 |
| Database Links | Reactome: R-HSA-1650814Reactome: R-HSA-264876Reactome: R-HSA-3299685Reactome: R-HSA-381426Reactome: R-HSA-5358346Reactome: R-HSA-8866423Reactome: R-HSA-8957275Reactome: R-HSA-8963888Reactome: R-HSA-8964041Reactome: R-HSA-9020591Reactome: R-HSA-9020933 |
| Cellular Localisation | Endoplasmic ReticulumEndoplasmic Reticulum LumenMelanosomeCell MembranePeripheral Membrane ProteinHighly AbundantIn Some Cell TypesSeems To Be Also Secreted Or Associated With The Plasma MembraneWhere It Undergoes Constant Shedding And Replacement From Intracellular Sources (Probable)Localizes Near Cd4-Enriched Regions On Lymphoid Cell SurfacesIdentified By Mass Spectrometry In Melanosome Fractions From Stage I To Stage IvColocalizes With Mttp In The Endoplasmic Reticulum |
| Alternative Antibody Names | Anti-Protein Disulfide-Isomerase antibodyAnti-Pdi antibodyAnti-Cellular Thyroid Hormone-Binding Protein antibodyAnti-Prolyl 4-Hydroxylase Subunit Beta antibodyAnti-P55 antibodyAnti-P4HB antibodyAnti-ERBA2L antibodyAnti-PDI antibodyAnti-PDIA1 antibodyAnti-PO4DB antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
