| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:1000-1:5000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | P4HA3 |
| Gene ID: | 283208 |
| Uniprot ID: | P4HA3_HUMAN |
| Immunogen Region: | 20-110 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-110 of human P4HA3 (NP_878907.1). |
| Immunogen Sequence: | DPERAAARGDTFSALTSVAR ALAPERRLLGLLRRYLRGEE ARLRDLTRFYDKVLSLHEDS TTPVANPLLAFTLIKRLQSD WRNVVHSLEAS |
| Tissue Specificity | Highly expressed in placenta, liver and fetal skin. Weakly expressed in fetal epiphyseal cartilage, fetal liver, fibroblast, lung and skeletal muscle. Expressed also in fibrous cap of carotid atherosclerotic lesions. |
| Post Translational Modifications | N-glycosylation plays no role in the catalytic activity. |
| Function | Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins. |
| Protein Name | Prolyl 4-Hydroxylase Subunit Alpha-34-Ph Alpha-3Procollagen-Proline -2-Oxoglutarate-4-Dioxygenase Subunit Alpha-3 |
| Database Links | Reactome: R-HSA-1650814 |
| Cellular Localisation | Endoplasmic Reticulum Lumen |
| Alternative Antibody Names | Anti-Prolyl 4-Hydroxylase Subunit Alpha-3 antibodyAnti-4-Ph Alpha-3 antibodyAnti-Procollagen-Proline -2-Oxoglutarate-4-Dioxygenase Subunit Alpha-3 antibodyAnti-P4HA3 antibodyAnti-UNQ711 antibodyAnti-PRO1374 antibody |
Information sourced from Uniprot.org