| Short Description : | Rabbit polyclonal anti-P2X1 (Cytoplasmic Domain) for use in IHC and WB in Mouse, Human, Rat and Marmoset samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | IHC/WB |
| Host: | Rabbit |
| Reactivity: | Mouse/Human/Rat/Marmoset |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Purification: | IgG purified |
| Dilution Range: | IHC, WB. A dilution of 1:2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Formulation: | Lyophilised |
| Storage Instruction: | Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Gene Symbol: | P2RX1 |
| Gene ID: | 5023 |
| Uniprot ID: | P2RX1_HUMAN |
| Immunogen: | A synthetic peptide from the cytoplasmic domain of human P2X1 conjugated to blue carrier protein was used as the antigen. The antigen shares 92% identity with rat and mouse sequence. |
| Immunogen Region: | Cytoplasmic Domain |
| Specificity: | Specific for P2RX1. |
| Function | ATP-gated nonselective transmembrane cation channel permeable to potassium, sodium and with relatively high calcium permeability. Furthermore, CTP functions as a weak affinity agonist for P2RX1. Plays a role a role in urogenital, immune and cardiovascular function. Specifically, plays an important role in neurogenic contraction of smooth muscle of the vas deferens, and therefore is essential for normal male reproductive function. In addition, contributes to smooth muscle contractions of the urinary bladder. On platelets, contributes to platelet activation and aggregation and thereby, also to thrombosis. On neutrophils, it is involved in chemotaxis and in mitigating the activation of circulating cells. |
| Protein Name | P2x Purinoceptor 1P2x1Atp ReceptorPurinergic Receptor |
| Database Links | Reactome: R-HSA-139853Reactome: R-HSA-418346Reactome: R-HSA-6798695 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinDetected At Plasma Membrane Lipid Rafts |
| Alternative Antibody Names | Anti-P2x Purinoceptor 1 antibodyAnti-P2x1 antibodyAnti-Atp Receptor antibodyAnti-Purinergic Receptor antibodyAnti-P2RX1 antibodyAnti-P2X1 antibody |
Information sourced from Uniprot.org