| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IF/ICC:1:10-1:100ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | P2RX4 |
| Gene ID: | 5025 |
| Uniprot ID: | P2RX4_HUMAN |
| Immunogen Region: | 55-338 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 55-338 of human P2RX4 (NP_002551.2). |
| Immunogen Sequence: | QETDSVVSSVTTKVKGVAVT NTSKLGFRIWDVADYVIPAQ EENSLFVMTNVILTMNQTQG LCPEIPDATTVCKSDASCTA GSAGTHSNGVSTGRCVAFNG SVKTCEVAAWCPVEDDTHVP QPAFLKAAENFTLLVKNNIW YPKFNFSKRNILPNITTTYL KSCIYDAKTDPFCPIFRLGK IVENAGHSFQDMAVEGGIMG IQVNWDCNLDRAASLCLPRY SFRRLDTRDVEHNVSPGYN |
| Function | ATP-gated nonselective transmembrane cation channel permeable to potassium, sodium and calcium. CTP, but not GTP or UTP, functions as a weak affinity agonist for P2RX4. Activated by extracellularly released ATP, it plays multiple role in immunity and central nervous system physiology. Plays a key role in initial steps of T-cell activation and Ca(2+) microdomain formation. Participates also in basal T-cell activity without TCR/CD3 stimulation. Promotes the differentiation and activation of Th17 cells via expression of retinoic acid-related orphan receptor C/RORC. Upon activation, drives microglia motility via the PI3K/Akt pathway. Could also function as an ATP-gated cation channel of lysosomal membranes. |
| Protein Name | P2x Purinoceptor 4P2x4Atp ReceptorPurinergic Receptor |
| Database Links | Reactome: R-HSA-139853Reactome: R-HSA-418346Reactome: R-HSA-9660826 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinLysosome Membrane |
| Alternative Antibody Names | Anti-P2x Purinoceptor 4 antibodyAnti-P2x4 antibodyAnti-Atp Receptor antibodyAnti-Purinergic Receptor antibodyAnti-P2RX4 antibody |
Information sourced from Uniprot.org