| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | Cdkn2a |
| Gene ID: | 12578 |
| Uniprot ID: | CDN2A_MOUSE |
| Immunogen Region: | 1-100 aa |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-100 of mouse p16 INK4A. (NP_001035744.1). |
| Immunogen Sequence: | MESAADRLARAAAQGRVHDV RALLEAGVSPNAPNSFGRTP IQVMMMGNVHVAALLLNYGA DSNCEDPTTFSRPVHDAARE GFLDTLVVLHGSGARLDVRD |
| Post Translational Modifications | Phosphorylation seems to increase interaction with CDK4. |
| Function | Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein. |
| Protein Name | Cyclin-Dependent Kinase Inhibitor 2a Cyclin-Dependent Kinase 4 Inhibitor A Cdk4i P16-Ink4a P16-Ink4 |
| Cellular Localisation | Cytoplasm Nucleus |
| Alternative Antibody Names | Anti-Cyclin-Dependent Kinase Inhibitor 2a antibody Anti-Cyclin-Dependent Kinase 4 Inhibitor A antibody Anti-Cdk4i antibody Anti-P16-Ink4a antibody Anti-P16-Ink4 antibody Anti-Cdkn2a antibody Anti-P16ink4a antibody |
Information sourced from Uniprot.org