Anti-P16 antibody [MX007] (STJ16101838)

SKU:
STJ16101838-1

£1,513.50
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Host: Mouse
Applications: IHC-P
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Mouse monoclonal antibody anti-P16 is suitable for use in Immunohistochemistry research applications.
Clonality: Monoclonal
Clone ID: MX007
Conjugation: Unconjugated
Isotype: IgGk
Formulation: Tissue culture supernatant containing 15mM sodium azide
Purification: Concentrate
Dilution Range: IHC-P 1:100-1:400
Storage Instruction: Store at 2-8°C upon receipt.
Background As one of the cyclin-dependent kinase inhibitors that inhibit cylcin-dependent kinases 4 and 6, p16INK4A is encoded by tumor suppressor gene CDKN2A. The tumor suppressor p16INK4A plays an important role in cell cycle regulation. Increased expression of the p16 gene, which is seen as organisms age, reduces the proliferation of stem cells. This reduction in the division and production of stem cells protects against cancer while increasing the risks associated with cellular senescence. Mutations in the p16 gene associated with loss or over expression of the protein are associated with increased risk of a wide range of cancers and cancer precursor lesions. The Immunohistochemical identification of p16 is particularly relevant in uterine cervical lesions: Development of dysplasia is closely related to human papilloma virus (HPV) infection. Pretreatment: Heat induced epitope retrieval in 10 mM citrate buffer, pH6.0, for 20 minutes is required for IHC staining on formalin-fixed, paraffin embedded tissue sections.Note: Dilution of the antibody in 10% normal goat serum followed by a goat anti-mouse secondary antibody-based detection is recommended. Control tissue Human cervical cancer, tonsil. Staining cytoplasmic and nuclear.

Information sourced from Uniprot.org

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