Anti-p120 catenin antibody [IHC120] (STJA0042231)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1
General Information
| Short Description | Mouse monoclonal anti-p120 catenin for use in IHC-p in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC-p |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | IHC120 |
| Isotype | IgG1 |
| Conjugation | Unconjugated |
| Formulation | Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide |
| Storage Instruction | Store at 2-8°C for up to 1 year. Do not freeze. |
Target Information
| Gene Symbol | CTNND1 |
| Gene ID | 1500 |
| Uniprot ID | CTND1_HUMAN |
| Specificity | Tested and validated on lobular breast carcinoma tissue. |
Additional Info
| Tissue Specificity | Expressed in vascular endothelium. Melanocytes and melanoma cells primarily express the long isoform 1A, whereas keratinocytes express shorter isoforms, especially 3A. The shortest isoform 4A, is detected in normal keratinocytes and melanocytes, and generally lost from cells derived from squamous cell carcinomas or melanomas. The C-terminal alternatively spliced exon B is present in the p120ctn transcripts in the colon, intestine and prostate, but lost in several tumor tissues derived from these organs. |
| Post Translational Modifications | Phosphorylated by FER and other protein-tyrosine kinases. Phosphorylated at Ser-288 by PAK5. Dephosphorylated by PTPRJ. |
| Function | Key regulator of cell-cell adhesion that associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability. Promotes localization and retention of DSG3 at cell-cell junctions, via its interaction with DSG3. Beside cell-cell adhesion, regulates gene transcription through several transcription factors including ZBTB33/Kaiso2 and GLIS2, and the activity of Rho family GTPases and downstream cytoskeletal dynamics. Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors. |
| Protein Name | Catenin Delta-1Cadherin-Associated Src SubstrateCasP120 CateninP120(CtnP120(Cas |
| Database Links | Reactome: R-HSA-418990Reactome: R-HSA-5218920Reactome: R-HSA-8876493Reactome: R-HSA-9762292Reactome: R-HSA-9764302Reactome: R-HSA-9833576 |
| Cellular Localisation | Cell JunctionAdherens JunctionCytoplasmNucleusCell MembraneInteraction With Glis2 Promotes Nuclear TranslocationDetected At Cell-Cell ContactsNanos1 Induces Its Translocation From Sites Of Cell-Cell Contact To The CytoplasmCdh1 Enhances Cell Membrane LocalizationLocalizes To Cell-Cell Contacts As Keratinocyte Differentiation ProgressesIsoform 1a: NucleusIsoform 2a: NucleusIsoform 3a: NucleusIsoform 4a: CytoplasmIsoform 1ab: Cytoplasm |
| Alternative Antibody Names | Anti-Catenin Delta-1 antibodyAnti-Cadherin-Associated Src Substrate antibodyAnti-Cas antibodyAnti-P120 Catenin antibodyAnti-P120(Ctn antibodyAnti-P120(Cas antibodyAnti-CTNND1 antibodyAnti-KIAA0384 antibody |
Information sourced from Uniprot.org