| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-OTU domain-containing protein 5 is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
OTUD5 |
| Gene ID: |
55593 |
| Uniprot ID: |
OTUD5_HUMAN |
| Specificity: |
This antibody detects endogenous levels of OTUD5 at Human, Mouse, Rat |
| Immunogen: |
Synthesized peptide derived from human OTUD5 |
| Post Translational Modifications | Phosphorylation at Ser-177 is required for deubiquitinating activity. Phosphorylation at Ser-328, Ser-337 and Ser-508 by MTOR promotes its activity. |
| Function | Deubiquitinating enzyme that functions as a negative regulator of the innate immune system. Has peptidase activity towards 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Can also cleave 'Lys-11'-linked ubiquitin chains (in vitro). Acts via TRAF3 deubiquitination and subsequent suppression of type I interferon (IFN) production. Controls neuroectodermal differentiation through cleaving 'Lys-48'-linked ubiquitin chains to counteract degradation of select chromatin regulators such as ARID1A, HDAC2 and HCF1. Acts as a positive regulator of mTORC1 and mTORC2 signaling following phosphorylation by MTOR: acts by mediating deubiquitination of BTRC, leading to its stability. |
| Protein Name | Otu Domain-Containing Protein 5Deubiquitinating Enzyme ADuba |
| Database Links | Reactome: R-HSA-5689896Reactome: R-HSA-936440 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Otu Domain-Containing Protein 5 antibodyAnti-Deubiquitinating Enzyme A antibodyAnti-Duba antibodyAnti-OTUD5 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
