| Post Translational Modifications | Phosphorylation at Ser-177 is required for deubiquitinating activity. Phosphorylation at Ser-328, Ser-337 and Ser-508 by MTOR promotes its activity. |
| Function | Deubiquitinating enzyme that functions as a negative regulator of the innate immune system. Has peptidase activity towards 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Can also cleave 'Lys-11'-linked ubiquitin chains (in vitro). Acts via TRAF3 deubiquitination and subsequent suppression of type I interferon (IFN) production. Controls neuroectodermal differentiation through cleaving 'Lys-48'-linked ubiquitin chains to counteract degradation of select chromatin regulators such as ARID1A, HDAC2 and HCF1. Acts as a positive regulator of mTORC1 and mTORC2 signaling following phosphorylation by MTOR: acts by mediating deubiquitination of BTRC, leading to its stability. |
| Protein Name | Otu Domain-Containing Protein 5Deubiquitinating Enzyme ADuba |
| Database Links | Reactome: R-HSA-5689896Reactome: R-HSA-936440 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Otu Domain-Containing Protein 5 antibodyAnti-Deubiquitinating Enzyme A antibodyAnti-Duba antibodyAnti-OTUD5 antibody |
Information sourced from Uniprot.org
