| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
OTUD5 |
| Gene ID: |
55593 |
| Uniprot ID: |
OTUD5_HUMAN |
| Immunogen Region: |
362-571 aa |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 362-571 of human OTUD5 (NP_060072.1). |
| Immunogen Sequence: |
QSLMKNAIKTSEESWIEQQM LEDKKRATDWEATNEAIEEQ VARESYLQWLRDQEKQARQV RGPSQPRKASATCSSATAAA SSGLEEWTSRSPRQRSSASS PEHPELHAELGMKPPSPGTV LALAKPPSPCAPGTSSQFSA GADRATSPLVSLYPALECRA LIQQMSPSAFGLNDWDDDEI LASVLAVSQQEYLDSMKKNK VHRDPPPDKS |
| Tissue Specificity | Expressed in various tissues, including the liver and placenta, as well as in peripheral blood leukocytes. |
| Post Translational Modifications | Phosphorylation at Ser-177 is required for deubiquitinating activity. Phosphorylation at Ser-328, Ser-337 and Ser-508 by MTOR promotes its activity. |
| Function | Deubiquitinating enzyme that functions as a negative regulator of the innate immune system. Has peptidase activity towards 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Can also cleave 'Lys-11'-linked ubiquitin chains (in vitro). Acts via TRAF3 deubiquitination and subsequent suppression of type I interferon (IFN) production. Controls neuroectodermal differentiation through cleaving 'Lys-48'-linked ubiquitin chains to counteract degradation of select chromatin regulators such as ARID1A, HDAC2 and HCF1. Acts as a positive regulator of mTORC1 and mTORC2 signaling following phosphorylation by MTOR: acts by mediating deubiquitination of BTRC, leading to its stability. |
| Protein Name | Otu Domain-Containing Protein 5Deubiquitinating Enzyme ADuba |
| Database Links | Reactome: R-HSA-5689896Reactome: R-HSA-936440 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Otu Domain-Containing Protein 5 antibodyAnti-Deubiquitinating Enzyme A antibodyAnti-Duba antibodyAnti-OTUD5 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
