| Host: |
Rabbit |
| Applications: |
IF/ICC/ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Monoclonal |
| Clone ID: |
SRM |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.09% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
IF/ICC:1:200-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
OTC |
| Gene ID: |
5009 |
| Uniprot ID: |
OTC_HUMAN |
| Immunogen Region: |
215-354 aa |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 215-354 of human OTC (NP_000522.3). |
| Immunogen Sequence: |
LQAATPKGYEPDASVTKLAE QYAKENGTKLLLTNDPLEAA HGGNVLITDTWISMGQEEEK KKRLQAFQGYQVTMKTAKVA ASDWTFLHCLPRKPEEVDDE VFYSPRSLVFPEAENRKWTI MAVMVSLLTDYSPQLQKPKF |
| Tissue Specificity | Mainly expressed in liver and intestinal mucosa. |
| Post Translational Modifications | Acetylation at Lys-88 negatively regulates ornithine carbamoyltransferase activity in response to nutrient signals. |
| Function | Catalyzes the second step of the urea cycle, the condensation of carbamoyl phosphate with L-ornithine to form L-citrulline. The urea cycle ensures the detoxification of ammonia by converting it to urea for excretion. |
| Protein Name | Ornithine Transcarbamylase - MitochondrialOtcaseOrnithine Carbamoyltransferase - Mitochondrial |
| Database Links | Reactome: R-HSA-1268020Reactome: R-HSA-70635 |
| Cellular Localisation | Mitochondrion Matrix |
| Alternative Antibody Names | Anti-Ornithine Transcarbamylase - Mitochondrial antibodyAnti-Otcase antibodyAnti-Ornithine Carbamoyltransferase - Mitochondrial antibodyAnti-OTC antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
