Anti-OSTC antibody (C-Term) (STJ119340)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal OSTC (C-Term) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:100-1:500ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | OSTC |
| Gene ID | 58505 |
| Uniprot ID | OSTC_HUMAN |
| Immunogen Region | C-Term |
| Immunogen Sequence | YDVIVEPPSVGSMTDEHGHQ RPVAFLAYRVNGQYIMEGLA SSFLFTMGGLGFIILDRSNA PNIPKLNRFLLLFIGFVCVL LSFFMARVFMRMKLPGYLMG |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 50 to the C-terminus of human OSTC (NP_067050.1). |
Additional Info
| Function | Subunit of STT3A-containing oligosaccharyl transferase (OST-A) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). Within the OST-A complex, acts as an adapter that anchors the OST-A complex to the Sec61 complex. May be involved in N-glycosylation of APP (amyloid-beta precursor protein). Can modulate gamma-secretase cleavage of APP by enhancing endoprotelysis of PSEN1. |
| Protein Name | Oligosaccharyltransferase Complex Subunit OstcHydrophobic Protein Hsf-28 |
| Database Links | |
| Cellular Localisation | Endoplasmic ReticulumMembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Oligosaccharyltransferase Complex Subunit Ostc antibodyAnti-Hydrophobic Protein Hsf-28 antibodyAnti-OSTC antibodyAnti-DC2 antibodyAnti-HDCMD45P antibodyAnti-HSPC307 antibody |
Information sourced from Uniprot.org