| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-OSTC (C-Term) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:100-1:500 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
OSTC |
| Gene ID: |
58505 |
| Uniprot ID: |
OSTC_HUMAN |
| Immunogen Region: |
C-Term |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 50 to the C-terminus of human OSTC (NP_067050.1). |
| Immunogen Sequence: |
YDVIVEPPSVGSMTDEHGHQ RPVAFLAYRVNGQYIMEGLA SSFLFTMGGLGFIILDRSNA PNIPKLNRFLLLFIGFVCVL LSFFMARVFMRMKLPGYLMG |
| Function | Specific component of the STT3A-containing form of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. May be involved in N-glycosylation of APP (amyloid-beta precursor protein). Can modulate gamma-secretase cleavage of APP by enhancing endoprotelysis of PSEN1. |
| Protein Name | Oligosaccharyltransferase Complex Subunit OstcHydrophobic Protein Hsf-28 |
| Cellular Localisation | Endoplasmic ReticulumMembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Oligosaccharyltransferase Complex Subunit Ostc antibodyAnti-Hydrophobic Protein Hsf-28 antibodyAnti-OSTC antibodyAnti-DC2 antibodyAnti-HDCMD45P antibodyAnti-HSPC307 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
