| Function | Subunit of STT3A-containing oligosaccharyl transferase (OST-A) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). Within the OST-A complex, acts as an adapter that anchors the OST-A complex to the Sec61 complex. May be involved in N-glycosylation of APP (amyloid-beta precursor protein). Can modulate gamma-secretase cleavage of APP by enhancing endoprotelysis of PSEN1. |
| Protein Name | Oligosaccharyltransferase Complex Subunit OstcHydrophobic Protein Hsf-28 |
| Database Links | |
| Cellular Localisation | Endoplasmic ReticulumMembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Oligosaccharyltransferase Complex Subunit Ostc antibodyAnti-Hydrophobic Protein Hsf-28 antibodyAnti-OSTC antibodyAnti-DC2 antibodyAnti-HDCMD45P antibodyAnti-HSPC307 antibody |
Information sourced from Uniprot.org
