| Function | Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane: specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds phosphatidylserine and PI4P in a mutually exclusive manner. Binds oxysterol, 25-hydroxycholesterol and cholesterol. |
| Protein Name | Oxysterol-Binding Protein-Related Protein 8Orp-8Osbp-Related Protein 8 |
| Database Links | Reactome: R-HSA-1482801 |
| Cellular Localisation | Isoform 1: Endoplasmic Reticulum MembraneSingle-Pass Membrane ProteinNucleus MembraneThe Presence Of The N-Terminus Extension Contains An Overall Negative Charge That May Explain The Weak Localization To The Cortical Endoplasmic Reticulum (Probable)Isoform 3: Endoplasmic Reticulum MembraneLocalizes To The Cortical Endoplasmic Reticulum At The Endoplasmic Reticulum-Plasma Membrane Contact Sites |
| Alternative Antibody Names | Anti-Oxysterol-Binding Protein-Related Protein 8 antibodyAnti-Orp-8 antibodyAnti-Osbp-Related Protein 8 antibodyAnti-OSBPL8 antibodyAnti-KIAA1451 antibodyAnti-ORP8 antibodyAnti-OSBP10 antibody |
Information sourced from Uniprot.org
