| Host: | Goat |
| Applications: | Pep-ELISA/WB/IHC/IF/FC |
| Reactivity: | Human/Mouse/Rat/Dog |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Goat polyclonal antibody anti-ORP5 (N-Term) is suitable for use in ELISA, Western Blot, Immunohistochemistry, Immunofluorescence and Flow Cytometry research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: | 0.5 mg/mL |
| Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:32000.WB: Approx. 100kDa band observed in lysates of cell line Jurkat and in Rat Spleen lysates (calculated MW of 98.4kDa according to Human NP_065947.1 and 101.7kDa according to Rat NP_00101502 |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: | OSBPL5 |
| Gene ID: | 114879 |
| Uniprot ID: | OSBL5_HUMAN |
| Immunogen Region: | N-Term |
| Accession Number: | NP_065947.1; NP_663613.1; NP_001137535.1 |
| Specificity: | This antibody is expected to recognise both reported isoforms. Variants (NP_663613.1; NP_001137535.1) encode the same isoform. |
| Immunogen Sequence: | KEEAFLRRRFSLC |
| Function | Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane: specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds phosphatidylserine and PI4P in a mutually exclusive manner. May cooperate with NPC1 to mediate the exit of cholesterol from endosomes/lysosomes. Binds 25-hydroxycholesterol and cholesterol. |
| Protein Name | Oxysterol-Binding Protein-Related Protein 5Orp-5Osbp-Related Protein 5Oxysterol-Binding Protein Homolog 1 |
| Database Links | Reactome: R-HSA-1482801 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Membrane ProteinLocalizes To Endoplasmic Reticulum-Plasma Membrane Contact Sites (Epcs)Localizes To The Cortical Endoplasmic Reticulum At The Epcs |
| Alternative Antibody Names | Anti-Oxysterol-Binding Protein-Related Protein 5 antibodyAnti-Orp-5 antibodyAnti-Osbp-Related Protein 5 antibodyAnti-Oxysterol-Binding Protein Homolog 1 antibodyAnti-OSBPL5 antibodyAnti-KIAA1534 antibodyAnti-OBPH1 antibodyAnti-ORP5 antibody |
Information sourced from Uniprot.org
