| Tissue Specificity | Highly expressed in tissues that contain well-developed endoplasmic reticulum and synthesize large amounts of secretory proteins. Highly expressed in liver and pancreas and lower expression in brain and kidney. Also expressed in macrophages within aortic atherosclerotic plaques, and in breast cancers. |
| Function | Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. Promotes HSPA5/BiP-mediated ATP nucleotide exchange and thereby activates the unfolded protein response (UPR) pathway in the presence of endoplasmic reticulum stress. May play a role as a molecular chaperone and participate in protein folding. |
| Protein Name | Hypoxia Up-Regulated Protein 1150 Kda Oxygen-Regulated ProteinOrp-150170 Kda Glucose-Regulated ProteinGrp-170Heat Shock Protein Family H Member 4 |
| Database Links | Reactome: R-HSA-3000484Reactome: R-HSA-381038 |
| Cellular Localisation | Endoplasmic Reticulum Lumen |
| Alternative Antibody Names | Anti-Hypoxia Up-Regulated Protein 1 antibodyAnti-150 Kda Oxygen-Regulated Protein antibodyAnti-Orp-150 antibodyAnti-170 Kda Glucose-Regulated Protein antibodyAnti-Grp-170 antibodyAnti-Heat Shock Protein Family H Member 4 antibodyAnti-HYOU1 antibodyAnti-GRP170 antibodyAnti-HSPH4 antibodyAnti-ORP150 antibody |
Information sourced from Uniprot.org
