| Host: |
Goat |
| Applications: |
Pep-ELISA/WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Goat polyclonal antibody anti-ORL1/LOX1/LOXIN (N-Term) is suitable for use in ELISA and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: |
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: |
0.5 mg/mL |
| Dilution Range: |
ELISA-antibody detection limit dilution 1:128000. |
| Storage Instruction: |
Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: |
OLR1 |
| Gene ID: |
4973 |
| Uniprot ID: |
OLR1_HUMAN |
| Immunogen Region: |
N-Term |
| Accession Number: |
NP_002534.1; NP_001166103.1; NP_001166104.1 |
| Specificity: |
This antibody is expected to recognize all reported isoforms (NP_002534.1; NP_001166103.1; NP_001166104.1). |
| Immunogen Sequence: |
DLKIQTVKDQPDEK |
| Post Translational Modifications | The intrachain disulfide-bonds prevent N-glycosylation at some sites. N-glycosylated. |
| Function | Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria. (Microbial infection) May serve as a receptor for adhesin A variant 3 (nadA) of N.meningitidis. |
| Protein Name | Oxidized Low-Density Lipoprotein Receptor 1Ox-Ldl Receptor 1C-Type Lectin Domain Family 8 Member ALectin-Like Oxidized Ldl Receptor 1Lox-1Lectin-Like Oxldl Receptor 1Hlox-1Lectin-Type Oxidized Ldl Receptor 1 Cleaved Into - Oxidized Low-Density Lipoprotein Receptor 1 - Soluble Form |
| Database Links | Reactome: R-HSA-202733Reactome: R-HSA-6798695 |
| Cellular Localisation | Cell MembraneLipid-AnchorSingle-Pass Type Ii Membrane ProteinMembrane RaftSecretedA Secreted Form Also ExistsLocalization To Membrane Rafts Requires Palmitoylation |
| Alternative Antibody Names | Anti-Oxidized Low-Density Lipoprotein Receptor 1 antibodyAnti-Ox-Ldl Receptor 1 antibodyAnti-C-Type Lectin Domain Family 8 Member A antibodyAnti-Lectin-Like Oxidized Ldl Receptor 1 antibodyAnti-Lox-1 antibodyAnti-Lectin-Like Oxldl Receptor 1 antibodyAnti-Hlox-1 antibodyAnti-Lectin-Type Oxidized Ldl Receptor 1 Cleaved Into - Oxidized Low-Density Lipoprotein Receptor 1 - Soluble Form antibodyAnti-OLR1 antibodyAnti-CLEC8A antibodyAnti-LOX1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
