Anti-Orexin A antibody (1-50) {Biotin} (STJ502012)

SKU:
STJ502012-100

Shipping:
Free Shipping
Current Stock:
Host: Rabbit
Applications: ELISA/IHC/IP/WB
Reactivity: Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Orexin A (1-50) is suitable for use in ELISA, Immunohistochemistry, Immunoprecipitation and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Biotin
Isotype: IgG
Purification: Affinity Purified
Concentration: 0.64-0.72 µg/µl
Dilution Range: WB: 1:500
DB: 1:10, 000
ELISA: 1:10, 000
IP: 1:200
IHC: 1:100
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: Hcrt
Gene ID: 15171
Uniprot ID: OREX_MOUSE
Immunogen Region: 1-50
Immunogen: Synthetic peptide taken within amino acid region 1-50 on ORXN protein.
Tissue Specificity Restricted to neuronal cell bodies of the dorsal and lateral hypothalamus.
Post Translational Modifications Specific enzymatic cleavages at paired basic residues yield the different active peptides.
Function Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Orexin-A: Binds to orexin receptors HCRTR1/OX1R and HCRTR2/OX2R with a high affinity. Stimulates food intake. Modulates pituitary luteinizing hormone secretion in an ovarian steroid-dependent manner. Orexin-B: Binds to orexin receptor HCRTR2/OX2R only. Stimulates food intake. Modulates pituitary luteinizing hormone secretion in an ovarian steroid-dependent manner.
Protein Name Hypocretin Neuropeptide Precursor
Hypocretin
Hcrt
Orexin Precursor
Prepro-Orexin
Preprohypocretin Cleaved Into - Orexin-A
Hypocretin-1
Hcrt1 - Orexin-B
Hypocretin-2
Hcrt2
Database Links Reactome: R-MMU-389397
Reactome: -MMU-416476
Cellular Localisation Rough Endoplasmic Reticulum
Cytoplasmic Vesicle
Synapse
Associated With Perikaryal Rough Endoplasmic Reticulum As Well As Cytoplasmic Large Granular Vesicles At Synapses
Alternative Antibody Names Anti-Hypocretin Neuropeptide Precursor antibody
Anti-Hypocretin antibody
Anti-Hcrt antibody
Anti-Orexin Precursor antibody
Anti-Prepro-Orexin antibody
Anti-Preprohypocretin Cleaved Into - Orexin-A antibody
Anti-Hypocretin-1 antibody
Anti-Hcrt1 - Orexin-B antibody
Anti-Hypocretin-2 antibody
Anti-Hcrt2 antibody
Anti-Hcrt antibody
Anti-Ox antibody
Anti-Ppox antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance