| Function | G-protein coupled opioid receptor that functions as a receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as a receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions. |
| Protein Name | Kappa-Type Opioid ReceptorK-Or-1Kor-1 |
| Database Links | Reactome: R-HSA-375276Reactome: R-HSA-418594Reactome: R-HSA-9022699 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Nanobody Names | Anti-Kappa-Type Opioid Receptor nanobodyAnti-K-Or-1 nanobodyAnti-Kor-1 nanobodyAnti-OPRK1 nanobodyAnti-OPRK nanobody |
Information sourced from Uniprot.org
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![Anti-OPRK1 nanobody [SAA1169] (STJN000215)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/200828/413010/STJN000215-SDS-PAGE-1__36142.1749232528.jpg?c=1 "Anti-OPRK1 nanobody [SAA1169] (STJN000215)")
