• Immunofluorescence analysis of MCF7 cells, using Encephalopsin Antibody. The picture on the right is blocked with the synthesized peptide.
  • Western blot analysis of lysates from mouse brain, using Encephalopsin Antibody. The lane on the right is blocked with the synthesized peptide.
  • Western blot analysis of various cell Lysate, antibody was diluted at 1:1000. Secondary antibody was diluted at 1:20000

Anti-OPN3 antibody (161-210 aa) (STJ92919)

SKU:
STJ92919

€57.50 - €282.50
Current Stock:
Host: Rabbit
Applications: WB/IHC/IF/ELISA
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Opsin-3 (161-210 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
IHC 1:100-1:300
IF 1:200-1:1000
ELISA 1:5000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: OPN3
Gene ID: 23596
Uniprot ID: OPN3_HUMAN
Immunogen Region: 161-210 aa
Specificity: Encephalopsin Polyclonal Antibody detects endogenous levels of Encephalopsin protein.
Immunogen: The antiserum was produced against synthesized peptide derived from the human Encephalopsin at the amino acid range 161-210
Function G-protein coupled receptor which selectively activates G proteins via ultraviolet A (UVA) light-mediated activation in the skin. Binds both 11-cis retinal and all-trans retinal. Regulates melanogenesis in melanocytes via inhibition of alpha-MSH-induced MC1R-mediated cAMP signaling, modulation of calcium flux, regulation of CAMK2 phosphorylation, and subsequently phosphorylation of CREB, p38, ERK and MITF in response to blue light. Plays a role in melanocyte survival through regulation of intracellular calcium levels and subsequent BCL2/RAF1 signaling. Additionally regulates apoptosis via cytochrome c release and subsequent activation of the caspase cascade. Required for TYR and DCT blue light-induced complex formation in melanocytes. Involved in keratinocyte differentiation in response to blue-light. Required for the UVA-mediated induction of calcium and mitogen-activated protein kinase signaling resulting in the expression of MMP1, MMP2, MMP3, MMP9 and TIMP1 in dermal fibroblasts. Plays a role in light-mediated glucose uptake, mitochondrial respiration and fatty acid metabolism in brown adipocyte tissues. May be involved in photorelaxation of airway smooth muscle cells, via blue-light dependent GPCR signaling pathways.
Protein Name Opsin-3
Encephalopsin
Panopsin
Database Links Reactome: R-HSA-418594
Reactome: R-HSA-419771
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Cytoplasm
Alternative Antibody Names Anti-Opsin-3 antibody
Anti-Encephalopsin antibody
Anti-Panopsin antibody
Anti-OPN3 antibody
Anti-ECPN antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance